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KMID : 0361019960390010045
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Korean Journal of Otolaryngology - Head and Neck Surgery
1996 Volume.39 No. 1 p.45 ~ p.50
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Expression of E-cadherin in Squamous Cell Carcinomas of the Head and Neck
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유창용
김상현/정병관/정덕희
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Abstract
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A characteristic feature of malignant tumor is that they invade surrounding tissues and form metastasis. Alterations in cell adhesion mechanisms may contribute to invasion. We investigated for the exepression of the epithelium-specific cell
adhesion
molecule E-cadherin in paraffin blocks of 42 squamous cell carcinomas of the head and neck. Among the 21 patients with lymph node metastasis, 11 patients did not show E-cadherin staining and 10 patients showed E-cadherin staining. Among the 21
patients
without lymph node metastasis, only 2 patients did not show E-cadherin staining. We found that E-cadherin exepression was inversely correlated with the dedifferentiation of the tumor an lymph node metastasis.
These data suggest that E-cadherin plays a important role in the progression of squamous cell carcinoma in the head and neck. (Korean J Otolaryngol 39 : 1, 1996)
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KEYWORD
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